Vitamin B12 serves as a crucial cofactor in enzymatic reactions with diverse physiological functions. It plays a vital role in converting methylmalonyl CoA to succinyl CoA and transforming homocysteine into methionine through methionine synthase, subsequently leading to the formation of S-adenosylmethionine. A deficiency in B12 disrupts these pathways, impacting neurological function by hindering the proper formation of myelin nerve sheaths, causing the production of elevated levels of homocysteine, and impeding efficient energy production in all cells. Methylcobalamin, the primary circulating form of B12 and the form transported into peripheral tissues, has demonstrated not only a reduction in homocysteine but also a decrease in inflammatory factors, carotid artery plaque volume among stroke patients, as well as alleviation of pain and neuropathy in diabetics.

Cobalamin is also essential for removing the methyl group from methyltetrahydrofolate, generating tetrahydrofolate, a crucial step in DNA synthesis. Consequently, B12 deficiency affects the development, function, and repair of all cells, with megaloblastic anemia being the most prominent sign due to inhibited mitosis of red blood cells. Certain individuals, particularly those with malabsorption or low dietary intake, face a higher risk of B12 deficiency. B12 in sublingual form, at a dosage of 1000 mcg per day, circumvents active absorption routes and can restore normal B12 levels, even in individuals with gastric bypass, pernicious anemia, and/or impaired absorptive capacity, showing greater efficacy than intramuscular injection.

Benefits

• Methylcobalamin is the active form of vitamin B12 for maximum benefit
• Superior bioavailability to the more common form, cyanocobalamin, which does not convert to enough methylcobalamin to correct some forms of anemia, neurological defects and aging1    
• Lowers homocysteine levels for protective cardiovascular benefits
• Sublingual tablets allow for fast acting delivery system directly into blood stream